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4 Beds
2 Baths
2,565 sqft

$1,000,000

422 21st St, Denver CO, 80205

Price per sqft$389.86
Built in1886
Property size2,565 sqft
Property typeResidential
Courtesy of Kentwood Commercial, Llc, Karen Zeile Listing Contact: [email protected],303-947-3665

Overview

Active

Listed Feb 10, 2026

Updated Aug 25

Rare and storied mixed-use opportunity situated on a highly visible 6,270-square-foot corner lot in the heart of Five Points. The property features a historic five-bedroom residence and a separate office building, totaling approximately 6,565 square feet of improvements on a single parcel. Ideally positioned just steps from Benedict Fountain Park, the RTD 27th & Welton Light Rail Station, neighborhood coffee shops and restaurants, and only minutes from Downtown Denver and Uptown, the property offers an exceptional blend of urban convenience, historic character, and neighborhood connectivity. The property includes an approximately 2,565-square-foot historic residence with five bedrooms and two bathrooms, currently operating as a successful Airbnb and providing immediate income or the opportunity for owner occupancy. Tucked behind the residence is a rare, private rear patio, offering an inviting outdoor retreat ideal for entertaining, relaxing, or complementing a live/work lifestyle-an uncommon amenity for a property so close to downtown. Complementing the residence is a separate office duplex totaling approximately 4,000 square feet, comprised of two approximately 2,000-square-foot office suites, one of which is currently leased on a month-to-month basis, providing immediate cash flow while preserving flexibility for future occupancy, repositioning, or redevelopment. Located within the Clements Historic District, this unique property offers exceptional visibility, walkability, and access to some of Denver's most desirable dining, entertainment, cultural, and transit amenities. Whether envisioned as an investment, corporate headquarters with supplemental income, creative office campus, live/work environment, boutique hospitality concept, or long-term repositioning opportunity, this one-of-a-kind asset presents remarkable versatility in one of Denver's most vibrant and historically significant neighborhoods.

$6,653/mo

Est. mortgage payment based on a $1,000,000 home price.

All estimates are provided by Luxury Presence for informational purposes only. Actual amounts may vary.

Additional information

MLS® ID
6487194

Interior Features

Bedrooms
4
Bathrooms
2
Heating
Yes
Basement
No

Exterior Features

Lot Size
0.14 Acres

Other Property Details

Taxes
$15,636
Tax Frequency
Annually
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Listings courtesy of Information and Real Estate Services, LLC (IRES) as distributed by MLS GRID

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